Androbiome Science
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Gut Microbiome and It's impact on Sperm Quality
Microbiome
The concept of the human microbiome was first introduced to the scientific community by Joshua Lederberg in 2001.
The microbiome is the ecological community of commensal, symbiotic and pathogenic microorganisms that fundamentally shape our lives health and diseased state.
Microorganism? Microbiota? Microbiome?
Micro-organisms are tiny organisms living in all kind of environment
Microbiota is a community of microorganisms in a specific environment
Microbiome is a collection of genetic material from all the micro-organisms that are part of the microbiota
Can alterations in the microbiome bring about changes in health?
Latest Metagenomic analysis reveals that human gut microbiome in each individual shares an identifiable core set of genes that are more highly protected than microbial composition.
Perturbations of core microbiome functions rather than core microbiota compositions, are altered in physiological and diseases states.
What is Microgenderome
Described as Di-morphism ( existence of two different forms) in microbiome.
It refers to the bi-directional interactions between microbiotas, sex hormones and immune systems.
It is highly relevant and different to male infertility & female infertility.
How does microbiome impact the Gut-Testis axis
The hypothesis of microbiota-gut-testis axis. Androgen or other communicating factors released by the testis remodel the gut microbiota.
Conversely, the gut microbiota affects the testicular function via endotoxin, induced ROS, or its metabolites (like SCFA), or via regulating gut metabolism and nutrition intake, or HPG axis.
The gut microbiota could be shaped by diet, lifestyle, toxins, drugs, probiotics, or other microbial regulators.
A summary of the theories supporting the interplay between androgen and gut microbiota. Androgen is involved in both the gender bias of diseases and the sex dimorphism of gut microbiome.
The“microgenderome” was proposed to describe the relationship among androgen, immune system and gut microbiota, while GELDING was a theory explaining the effect of gut microbiota on testosterone production by endotoxin.
Moreover, gut microbiota may be involved in testosterone metabolism by deglucuronidation activity or expressing steroid metabolizing enzymes.
GELDING, gut endotoxin leading to a decline in gonadal function; T-G, glucuronidated testosterone; DHT-G, glucuronidated dihydrotestosterone; HSDH, hydroxysteroid dehydrogenase
Critical Role of Gut Microbiome in Sperm DNA fragmentation
Specific role of probiotics and prebiotics (Fertibiotics) in improving sperm quality
It tightens the leaky gut and reduces pro inflammatory cytokines
It corrects Insulin resistance, improves Vitamin A metabolism, reduces chromatin damage and Reactive oxygen species
It creates homeostasis in the semen and testicular microbiome.
It significantly reduces Sperm DNA fragmentation